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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Fluoride (sodium) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | USA | OTC | Acidulated phosphate fluoride rinse (dental rinse). Dosage is 0.02% fluoride in aqueous solution (topical). Sodium fluoride rinse (dental rinse). Dosage is 0.05% aqueous solution (topical). Stannous fluoride gel (anti-cavities gel). Dosage is 0.4% gel (topical). Stannous fluoride rinse (dental rinse). Dosage is 0.1% aqueous solution (topical). |
| Hexetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | USA | — | No information. |
| Aluminium hydroxide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | OTC | For the relief of heartburn. |
| Calcium carbonate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | OTC | For the relief of heartburn. Maximum daily dose 8g. |
| Carbenoxolone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | — | No information. |
| Cetraxate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | — | No information. |
| Cimetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1995 | USA | OTC | Heartburn, acid reducer. 200mg up to twice a day, in adults and adolescents aged 12 years and over. |
| Famotidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1995 | USA | OTC | Heartburn, acid reducer. Adult dosage of 10mg up to 20mg per day. 12 years of age and older. |
| Lansoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2009 | USA | OTC | Lansoprazole 15mg delayed-release caspules. 14-day course of treatment for frequent heartburn approved for non-prescription use in May 2009, in adults aged 18 and over. |
| Nizatidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1996 | USA | OTC | Acid reducer, 75mg up to twice daily, in adults and adolescents aged 12 and over. |
| Omeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2003 | USA | OTC | Omeprazole 20mg/day acid reducer to treat frequent heartburn. 20mg Omeprazole and 1100mg Sodium bicarbonate to treat frequent heartburn switched to non-prescription status in December 2009. |
| Pantoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | Rx | — |
| Rabeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | Rx | — |
| Ranitidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1995 | USA | OTC | Heartburn, acid reducer. 150mg dose up to 2 times a day, in adults and adolescents aged 12 and over. |
| Sucralfate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | USA | Rx | — |
| Dicyclomine (Dicycloverine) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | Rx | — |
| Dimeticone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | — | No information |
| Domperidone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | Rx | — |
| Hyoscine butylbromide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | — | No information. |
| Mebeverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | — | No information. |
| Metoclopramide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | Rx | — |
| Propantheline | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | Rx | — |
| Dimenhydrinate (diphenhydramine and 8-chlorotheophylline) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A04. Antiemetics and antinauseants | — | USA | Rx | — |
| Hyoscine (Scopolamine) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A04. Antiemetics and antinauseants | — | USA | Rx | — |
| Hymecromone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A05. Bile and liver therapy | — | USA | Rx | — |
| Bisacodyl | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | USA | OTC | Laxative. 5mg. In children from 6 to under 12 years of age, dose: 1 tablet. From 12 years and older: 1 to 3 tablets in a single dose. |
| Lactitol | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | USA | — | No information. |
| Lactulose | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | USA | Rx | — |
| Macrogol (Polyethylene glycol 3350) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | 2006 | USA | OTC | Osmotic laxative. 17g powder stirred into a beverage, in adults and adolescents aged 17 and over. |
| Picosulfate (sodium) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | USA | Rx | — |
| Loperamide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | 1988 | USA | OTC | Antidiarrhoeal. Dosage for adults and children 12 and over is 4mg, then 2mg, up to 8mg/day (oral). Children 9-11: 2 mg, up to 6 mg/day. Children 6-8: 2 mg, up to 4 mg/daily |
| Nifuroxazide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | USA | — | No information. |
| Orlistat | A Alimentary tract and metabolism. Alimentary tract and metabolism | A08. Antiobesity preparations | 2007 | USA | OTC | Orlistat 60 mg capsules up to 3 times per day as a weight loss aid for overweight adults. |
| Vitamin A (Retinol) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A11. Vitamins | — | USA | Rx | Cosmetic in certain uses. |
| Selenium | A Alimentary tract and metabolism. Alimentary tract and metabolism | A12. Mineral supplements | — | USA | OTC | Dietary supplement. No authorized OTC medicine indications. |
| Tranexamic acid | B Blood and blood forming organs. Blood and blood forming organs | B02. Antihemorrhagics | — | USA | — | No information. |
| Adenosine | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | USA | Rx | — |
| Nitro-glycerine | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | USA | Rx | — |
| Ubidecarenone | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | USA | — | No information. |
| Lovastatin | C Cardiovascular system. Cardiovascular system | C10. Lipid modifying agents | — | USA | Rx | — |
| Simvastatin | C Cardiovascular system. Cardiovascular system | C10. Lipid modifying agents | — | USA | Rx | — |
| Amorolfine (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | — | No information. |
| Bifonazole | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | Rx | — |
| Butenafine | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | Rx | — |
| Ciclopirox Olamine | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | Rx | — |
| Clotrimazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 1989 | USA | OTC | Separate applications for antifungal for athlete's foot or jock itch, and as a vaginal antifungal, 1% lotion and cream, twice daily. |
| Croconazole | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | — | No information. |
| Econazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | Rx | — |
| Fenticonazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | — | No information. |
| Fluconazole | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | USA | — | No information. |
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