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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Estradiol (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | — | Italy | Rx | — |
| Bilastine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | Rx | — |
| Dexibuprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | — | Italy | OTC | — |
| lidocaine / prilocaine | R Respiratory system. Respiratory system | R01. Nasal preparations | 2020 | Italy | OTC | Lidocaine/prilocaine 150 mg/ml + 50 mg/ml cutaneous spray, solution was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 27 August 2020. It is indicated for the treatment of primary premature ejaculation in adult men. |
| Pholcodine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Italy | — | Revocation of all marketing authorisations for Pholcodine medicinal products in the EU due to serious allergic reactions and limited evidence of benefit. |
| Butamirate citrate | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Italy | — | No information. |
| Atovaquone/Proguanil | P Antiparasitic products, insecticides and repellents. Antiparasitic products, insecticides and repellents | P01. Antiprotozoals | — | Italy | — | No information. |
| Sildenafil | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Italy | Rx | — |
| Aciclovir (systemic use) | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Italy | Rx | — |
| Adapalene | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Italy | — | No information. |
| Dexketoprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | 2009 | Italy | OTC | 25mg tablets for the symptomatic treatment (short time) of general mild to moderate pain as: muscular, skeleton, dysmenorrhea, teeth. |
| Valaciclovir | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Italy | Rx | — |
| Econazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | Italy | OTC | OTC (advertising allowed). |
| Fusafungine | R Respiratory system. Respiratory system | R02. Throat preparations | — | Italy | N.R. | Not registered or not marketed. |
| Ulipristal acetate | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | 2015 | Italy | OTC | Ulipristal acetate 30mg was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 7 January 2015. It is indicated for emergency contraception within 120 hours (5 days) of unprotected sexual intercourse or contraceptive failure. In Italy, it has SOP (advertising not allowed) status, but a prescription is necessary for girls under 18 years of age. |
| Oxitriptan | N Nervous system. Nervous system | N06. Psychoanaleptics | — | Italy | Rx | — |
| Yohimbine | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Italy | N.R. | Not registered or not marketed. |
| Cetrimide | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Italy | N.R. | Not registered or not marketed. |
| Azelaic acid | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | 2007 | Italy | OTC | — |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | Italy | OTC | SOP (behind the counter). |
| Metronidazole | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | 2012 | Italy | OTC | Without prescription - SOP (advertising not allowed). Also SOP under ATC code G01. |
| Desloratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2020 | Italy | OTC | Desloratadine 5 mg film-coated tablets was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 24 November 2020. It is indicated indicated in adults for the relief of symptoms associated with: - allergic rhinitis - chronic idiopathic urticaria as initially diagnosed by a physician |
| Antazoline | S Sensory organs. Sensory organs | S01. Ophthalmologicals | 2008 | Italy | OTC | In combination with naftazoline. |
| Neomycin sulfate | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Italy | OTC | OTC only in combination. The active ingredient alone present in herbal products (no drug). |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Italy | Rx | — |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | N.R. | Not registered or not marketed. |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Italy | OTC | Also OTC under ATC codes D08 and G01. |
| Chloroxylenol | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Italy | OTC | In combination. Also OTC, in combination, under ATC code D04. |
| Isoconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | 2012 | Italy | OTC | SOP (behind the counter). |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2013 | Italy | OTC | Esomeprazole 20mg was switched to non-prescription status under the centralised procedure in the entire European Union through a European Commission Decision dated 26 August 2013. It is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. Recommended daily dose: one 20mg gastroresistant tablet. Maximum duration of treatment: 2 weeks. |
| Trimethoprim | J Antiinfectives for systemic use. Antiinfectives for systemic use | J01. Antibacterials for systemic use | — | Italy | Rx | In association with sulphametazole. |
| Oxybutynin | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Italy | Rx | — |
| Lodoxamide | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Italy | N.R. | Not registered or not marketed. |
| Guaifenesin | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Italy | OTC | Alone or in combination. |
| Erdosteine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Italy | Rx | — |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Italy | Rx | — |
| Strontium chloride (toothpaste) | Non-classified -. - | n. a. | — | Italy | N.R. | Not registered or not marketed. |
| Potassium nitrate (toothpaste) | Non-classified -. - | n. a. | — | Italy | N.R. | Not registered or not marketed as medicinal product. |
| Decaline | Non-classified -. - | n. a. | — | Italy | N.R. | Not registered or not marketed. |
| Bronopol | Non-classified -. - | n. a. | — | Italy | — | Veterinary use. In short disposal. |
| Polymyxin B (topical) | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Italy | OTC | Not registered or not marketed under this ATC code. SOP (advertising not allowed) since 2008 under ATC code S01 (in combination with lidocaine + neomycin). |
| Chloramphenicol | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Italy | Rx | — |
| Sulfacetamide (topical) | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Italy | OTC | SOP (advertising not allowed). Sulfacetamide 3g in combination with different ingredients. |
| Trip(r)olidine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | OTC | Not registered or not marketed under this ATC code. OTC under ATC codes R05 (in combination with pseudoephedrine + dextromethorphan) and R01 (in combination with pseudoephedrine and pseudoephedrine + paracetamol). |
| Tripelennamine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | N.R. | Not registered or not marketed. |
| Promethazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | OTC | Rx under this ATC code. OTC (advertising allowed) under ATC codes D04. |
| Oxatomide | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | OTC | Rx under this ATC code. Without prescription - SOP (advertising not allowed) since 2008 under ATC code D04 as 5% gel, 30g. |
| Mequitazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | N.R. | Not registered or not marketed. |
| Mepyramine maleate | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | N.R. | Not registered or not marketed. |
| Meclozine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Italy | N.R. | Not registered or not marketed. |
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