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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Estradiol (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | — | Germany | Rx | — |
| Levodropropizine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | 2022 | Germany | OTC | — |
| Bilastine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2022 | Germany | OTC | 20 mg; oral use; hay fever, adults over 12 years |
| lidocaine / prilocaine | N Nervous system. Nervous system | N01. Anesthetics | 2020 | Germany | OTC | Lidocaine/prilocaine 150 mg/ml + 50 mg/ml cutaneous spray, solution was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 27 August 2020. It is indicated for the treatment of primary premature ejaculation in adult men. |
| Pholcodine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Germany | N.R. | Revocation of all marketing authorisations for Pholcodine medicinal products in the EU due to serious allergic reactions and limited evidence of benefit. |
| Butamirate citrate | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Germany | — | No information. |
| Atovaquone/Proguanil | P Antiparasitic products, insecticides and repellents. Antiparasitic products, insecticides and repellents | P01. Antiprotozoals | — | Germany | — | No information. |
| Sildenafil | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Germany | Rx | — |
| Aciclovir (systemic use) | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Germany | Rx | — |
| Adapalene | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Germany | Rx | — |
| Dexketoprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | — | Germany | Rx | — |
| Valaciclovir | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Germany | — | No information. |
| Econazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | Germany | Rx | — |
| Fusafungine | R Respiratory system. Respiratory system | R02. Throat preparations | — | Germany | N.R. | Revocation of all marketing authorisations for fusafungine sprays in the EU due to serious allergic reactions and limited evidence of benefit. Previous status: OTC. |
| Ulipristal acetate | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | 2015 | Germany | OTC | Ulipristal acetate 30mg was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 7 January 2015. It is indicated for emergency contraception within 120 hours (5 days) of unprotected sexual intercourse or contraceptive failure. |
| Oxitriptan | N Nervous system. Nervous system | N06. Psychoanaleptics | — | Germany | N.R. | Not registered or not marketed. |
| Yohimbine | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Germany | Rx | — |
| Cetrimide | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Germany | OTC | Not registered or not marketed under ATC code D08. OTC under ATC code S01. |
| Azelaic acid | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Germany | Rx | — |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | Germany | N.R. | Not registered or not marketed. |
| Metronidazole | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Germany | Rx | — |
| Desloratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | OTC | Desloratadine 5 mg film-coated tablets was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 24 November 2020. It is indicated indicated in adults for the relief of symptoms associated with: - allergic rhinitis - chronic idiopathic urticaria as initially diagnosed by a physician |
| Antazoline | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Germany | OTC | — |
| Neomycin sulfate | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Germany | N.R. | Not registered or not marketed. |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Germany | OTC | — |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Germany | N.R. | Not registered or not marketed. |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Germany | OTC | Also OTC under ATC code D08. |
| Chloroxylenol | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Germany | OTC | Not registered or not marketed under this ATC code. OTC under ATC code A01. |
| Isoconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | Germany | N.R. | Not registered or not marketed. |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2013 | Germany | OTC | Esomeprazole 20mg was switched to non-prescription status under the centralised procedure in the entire European Union through a European Commission Decision dated 26 August 2013. It is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. Recommended daily dose: one 20mg gastroresistant tablet. Maximum duration of treatment: 2 weeks. |
| Trimethoprim | J Antiinfectives for systemic use. Antiinfectives for systemic use | J01. Antibacterials for systemic use | — | Germany | Rx | — |
| Oxybutynin | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Germany | Rx | — |
| Lodoxamide | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Germany | OTC | — |
| Guaifenesin | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Germany | OTC | — |
| Erdosteine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Germany | N.R. | Not registered or not marketed. |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | 2013 | Germany | OTC | Solid dosage forms. For the treatment of acute diarrhoea, maximum duration of treatment 3 days. Adults (over 18 years): 100mg per dosage form, maximum pack size 1,000mg. Children aged 12 years and older: Racecadotril 30mg per single dose in combination with oral re-hydration, maximum pack size 450mg. |
| Strontium chloride (toothpaste) | Non-classified -. - | n. a. | — | Germany | N.R. | Cosmetic. |
| Potassium nitrate (toothpaste) | Non-classified -. - | n. a. | — | Germany | N.R. | Cosmetic. |
| Decaline | Non-classified -. - | n. a. | — | Germany | — | Classified as an antiseptic, solution for intraocular use. |
| Bronopol | Non-classified -. - | n. a. | — | Germany | — | Used as excipient. |
| Polymyxin B (topical) | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Germany | Rx | — |
| Chloramphenicol | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Germany | Rx | — |
| Sulfacetamide (topical) | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Germany | Rx | — |
| Trip(r)olidine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | OTC | — |
| Tripelennamine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | OTC | — |
| Promethazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | Rx | — |
| Oxatomide | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | Rx | — |
| Mequitazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | Rx | — |
| Mepyramine maleate | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | OTC | No product currently marketed. |
| Meclozine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Germany | Rx | — |
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