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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Pholcodine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Canada | N.R. | Not registered or not marketed. |
| Butamirate citrate | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Canada | — | No information. |
| Atovaquone/Proguanil | P Antiparasitic products, insecticides and repellents. Antiparasitic products, insecticides and repellents | P01. Antiprotozoals | — | Canada | — | No information. |
| Sildenafil | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Canada | Rx | — |
| Adapalene | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Canada | Rx | — |
| Dexketoprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | — | Canada | N.R. | Not registered or not marketed. |
| Valaciclovir | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Canada | N.R. | Not registered or not marketed. |
| Econazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | Canada | — | No information. |
| Fusafungine | R Respiratory system. Respiratory system | R02. Throat preparations | — | Canada | N.R. | Not registered or not marketed. |
| Ulipristal acetate | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | — | Canada | Rx | — |
| Oxitriptan | N Nervous system. Nervous system | N06. Psychoanaleptics | — | Canada | N.R. | Not registered or not marketed. |
| Yohimbine | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Canada | Rx | — |
| Cetrimide | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Canada | OTC | Ethical OTC status (medicine which does not require a prescription but is generally prescribed by a medical practitioner). |
| Azelaic acid | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Canada | Rx | — |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | Canada | N.R. | Not registered or not marketed. |
| Metronidazole | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Canada | Rx | — |
| Desloratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2005 | Canada | OTC | — |
| Antazoline | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Canada | Rx | — |
| Neomycin sulfate | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Canada | Rx | — |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Canada | N.R. | Not registered or not marketed. |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Canada | Rx | — |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | 2013 | Canada | OTC | Topical oral preparation (Schedule 1). |
| Chloroxylenol | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Canada | OTC | Miscellaneous local anti-infectives (liquid). |
| Isoconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | Canada | N.R. | Not registered or not marketed. |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2016 | Canada | OTC | For the 14-day treatment for frequent heartburn at a daily dose of 20mg. |
| Trimethoprim | J Antiinfectives for systemic use. Antiinfectives for systemic use | J01. Antibacterials for systemic use | — | Canada | Rx | — |
| Oxybutynin | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Canada | Rx | — |
| Lodoxamide | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Canada | Rx | — |
| Guaifenesin | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Canada | OTC | Expectorant. |
| Erdosteine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Canada | N.R. | Not registered or not marketed. |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Canada | N.R. | Not registered or not marketed. |
| Strontium chloride (toothpaste) | Non-classified -. - | n. a. | 1998 | Canada | OTC | Regulated as a natural health product. |
| Potassium nitrate (toothpaste) | Non-classified -. - | n. a. | 2013 | Canada | OTC | Regulated as a natural health product. |
| Decaline | Non-classified -. - | n. a. | — | Canada | N.R. | Not registered or not marketed. |
| Bronopol | Non-classified -. - | n. a. | — | Canada | OTC | Antiseptic hand soap. |
| Polymyxin B (topical) | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | 2006 | Canada | OTC | — |
| Chloramphenicol | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Canada | Rx | — |
| Sulfacetamide (topical) | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Canada | Rx | — |
| Trip(r)olidine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1998 | Canada | OTC | — |
| Tripelennamine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1998 | Canada | OTC | Not registered or not marketed under this ATC code. OTC under ATC code D04 (antihistamines for topical use). |
| Promethazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1998 | Canada | OTC | — |
| Oxatomide | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Canada | N.R. | Not registered or not marketed. |
| Mequitazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Canada | N.R. | Not registered or not marketed. |
| Mepyramine maleate | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Canada | N.R. | Not registered or not marketed. |
| Meclozine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2000 | Canada | OTC | 25mg, for the prevention and treatment of nausea. No longer marketed. |
| Loratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1988 | Canada | OTC | On 22 September 2002, the Nonprescription Drug Scheduling Advisory Committee recommended that loratadine and its salts and preparations in products marketed for adult use (age 12 years and over) be unscheduled (i.e. available on general sale). Loratadine marketed for paediatric use (under 12 years) will remain Schedule 3 (available without a prescription, these drugs are to be sold from the self-selection area of the pharmacy which is operated under the direct supervision of the pharmacist). |
| Levocetirizine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Canada | N.R. | Not registered or not marketed. |
| Ketotifen | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Canada | Rx | — |
| Fexofenadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2007 | Canada | OTC | Schedule 3 (available without a prescription but to be sold from the self-selection area of the pharmacy which is operated under the direct supervision of the pharmacist) for products marketed for paediatric use (under 12 years of age). |
| Epinastine hydrochloride | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Canada | N.R. | Not registered or not marketed. |
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