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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Pholcodine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Japan | — | No information. |
| Butamirate citrate | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Japan | — | No information. |
| Atovaquone/Proguanil | P Antiparasitic products, insecticides and repellents. Antiparasitic products, insecticides and repellents | P01. Antiprotozoals | — | Japan | — | No information. |
| Sildenafil | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Japan | Rx | — |
| Aciclovir (systemic use) | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Japan | Rx | — |
| Adapalene | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Japan | Rx | — |
| Dexketoprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | — | Japan | N.R. | — |
| Valaciclovir | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | Japan | Rx | — |
| Econazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | Japan | N.R. | — |
| Fusafungine | R Respiratory system. Respiratory system | R02. Throat preparations | — | Japan | N.R. | — |
| Ulipristal acetate | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | — | Japan | N.R. | — |
| Oxitriptan | N Nervous system. Nervous system | N06. Psychoanaleptics | — | Japan | N.R. | — |
| Yohimbine | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Japan | OTC | BTC |
| Cetrimide | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Japan | OTC | — |
| Azelaic acid | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | Japan | N.R. | — |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | Japan | N.R. | — |
| Metronidazole | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Japan | Rx | — |
| Desloratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | Rx | — |
| Antazoline | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Japan | N.R. | Not registered or not marketed. |
| Neomycin sulfate | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | Japan | OTC | Discontinued. |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Japan | OTC | Micro granules. 3000mg per dose up to three times a day for adults and adolescents 15 years of age and over. For children aged between 11 and 14, 2/3 of the dose for adults. |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | N.R. | — |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Japan | OTC | Antimicrobial for external use. |
| Chloroxylenol | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | Japan | N.R. | — |
| Isoconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | 2008 | Japan | OTC | Vaginal tablet. Daily dose 100mg. 1% cream for external use of vulvar candidiasis, 2-3 times a day. |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | Rx | — |
| Trimethoprim | J Antiinfectives for systemic use. Antiinfectives for systemic use | J01. Antibacterials for systemic use | — | Japan | Rx | Combinations trimethoprim + sulfamethoxazole. |
| Oxybutynin | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | Japan | Rx | — |
| Lodoxamide | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Japan | N.R. | Not registered or not marketed. |
| Guaifenesin | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Japan | OTC | — |
| Erdosteine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | Japan | N.R. | — |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Japan | N.R. | — |
| Strontium chloride (toothpaste) | Non-classified -. - | n. a. | — | Japan | Rx | — |
| Potassium nitrate (toothpaste) | Non-classified -. - | n. a. | — | Japan | OTC | Toothpaste for over-sensitivity as a quasi-drug. |
| Decaline | Non-classified -. - | n. a. | — | Japan | N.R. | — |
| Bronopol | Non-classified -. - | n. a. | — | Japan | N.R. | — |
| Polymyxin B (topical) | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Japan | OTC | Rx and OTC under ATC code D01. Ointment formulation. 10,000 units per gram in topical combination drug with oxytetracycline hydrochloride. |
| Chloramphenicol | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | Japan | OTC | OTC under ATC code D06. |
| Sulfacetamide (topical) | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | Japan | N.R. | — |
| Trip(r)olidine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | OTC | — |
| Tripelennamine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | OTC | — |
| Promethazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | OTC | — |
| Oxatomide | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | Rx | — |
| Mequitazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1990 | Japan | OTC | 2mg a dose, twice a day for adults and adolescents 15 years of age and over. The dose increased to 3mg a dose, twice a day for adults and adolescents 15 years of age and over in 2011. Also OTC as cold and rhinitis remedies, 1.33mg a dose, three times a day for adults and adolescents 15 years of age and over. |
| Mepyramine maleate | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | N.R. | — |
| Meclozine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1990 | Japan | OTC | Alternative name: Mecridine. |
| Loratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2017 | Japan | OTC | BTC. Tablets: 10mg per day for adults and adolescents 15 years of age and over. |
| Levocetirizine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | Japan | Rx | — |
| Ketotifen | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2006 | Japan | OTC | 1mg a dose, twice a day for adults and adolescents 15 years of age and over. Also OTC as nasal drops under ATC code R01 since 2005 and as 0.05% allergy eye drops under ATC code S01 since 2007. |
| Fexofenadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2012 | Japan | OTC | 60mg a dose, twice a day for adults and adolescents 15 years of age and over. Additional dosage for adolescents 7-11 and 12-14 years of age, respectively 30mg and 60mg a dose, twice a day switched in 2017. |
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