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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| lidocaine / prilocaine | N Nervous system. Nervous system | N01. Anesthetics | — | USA | — | — |
| Pholcodine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | USA | N.R. | Not registered or not marketed. |
| Butamirate citrate | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | USA | — | No information. |
| Atovaquone/Proguanil | P Antiparasitic products, insecticides and repellents. Antiparasitic products, insecticides and repellents | P01. Antiprotozoals | — | USA | — | No information. |
| Sildenafil | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | USA | Rx | — |
| Aciclovir (systemic use) | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | USA | — | No information. |
| Adapalene | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | 2016 | USA | OTC | Acne treatment. 0.1% gel, once daily. |
| Dexketoprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | — | USA | — | No information. |
| Valaciclovir | J Antiinfectives for systemic use. Antiinfectives for systemic use | J05. Antivirals for systemic use | — | USA | Rx | — |
| Econazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | USA | Rx | — |
| Fusafungine | R Respiratory system. Respiratory system | R02. Throat preparations | — | USA | — | No information. |
| Ulipristal acetate | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | — | USA | Rx | — |
| Oxitriptan | N Nervous system. Nervous system | N06. Psychoanaleptics | — | USA | — | No information. |
| Yohimbine | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | — | USA | — | No information. |
| Cetrimide | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | USA | — | No information. |
| Azelaic acid | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | — | USA | Rx | — |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | USA | — | No information. |
| Metronidazole | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | USA | Rx | — |
| Desloratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | Rx | — |
| Antazoline | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | USA | Rx | — |
| Neomycin sulfate | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | — | USA | OTC | First aid ointment. |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | USA | — | No information. |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | USA | — | No information. |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | USA | OTC | Chlorhexidine gluconate 4% antiseptic/antimicrobial skin cleanser. |
| Chloroxylenol | D Dermatologicals. Dermatologicals | D08. Antiseptics and disinfectants | — | USA | — | No information. |
| Isoconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | — | USA | — | No information. |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2014 | USA | OTC | Frequent heartburn, acid reducer. Daily dose 20mg, in adults aged 18 and over. |
| Trimethoprim | J Antiinfectives for systemic use. Antiinfectives for systemic use | J01. Antibacterials for systemic use | — | USA | Rx | — |
| Oxybutynin | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G04. Urologicals | 2013 | USA | OTC | For the treatment of overactive bladder in women aged 18 years and older. 3.9mg patch (daily). |
| Lodoxamide | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | USA | Rx | — |
| Guaifenesin | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | USA | OTC | Expectorant. |
| Erdosteine | R Respiratory system. Respiratory system | R05. Cough and cold preparations | — | USA | — | No information. |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | USA | — | No information. |
| Strontium chloride (toothpaste) | Non-classified -. - | n. a. | — | USA | N.R. | Not registered or not marketed. |
| Potassium nitrate (toothpaste) | Non-classified -. - | n. a. | — | USA | OTC | — |
| Decaline | Non-classified -. - | n. a. | — | USA | — | No information. |
| Bronopol | Non-classified -. - | n. a. | — | USA | N.R. | Not registered or not marketed. |
| Polymyxin B (topical) | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | USA | OTC | — |
| Chloramphenicol | S Sensory organs. Sensory organs | S03. Ophthalmological and otological preparations | — | USA | Rx | — |
| Sulfacetamide (topical) | S Sensory organs. Sensory organs | S01. Ophthalmologicals | — | USA | Rx | — |
| Trip(r)olidine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 1982 | USA | OTC | Triprolidine hydrochloride as antihistamine. Adult dosage is 2.5mg/4-6 hours. In 1985, triprolidine HCl was approved OTC with a dosage of 5mg / 12 hours. |
| Tripelennamine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | Rx | — |
| Promethazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | Rx | — |
| Oxatomide | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | — | No information. |
| Mequitazine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | — | No information. |
| Mepyramine maleate | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | — | No information. |
| Meclozine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | — | USA | — | No information. |
| Loratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2002 | USA | OTC | 10mg/day tablets or syrup antihistamine for hives relief. |
| Levocetirizine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2017 | USA | OTC | 5mg antihistamine, 1 tablet daily. |
| Ketotifen | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2006 | USA | OTC | Ketotifen 0.025% ophthalmic solution switched to non-prescription status in 2006. |
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