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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Hexetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Italy | OTC | — |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Italy | OTC | Also OTC under ATC codes D08 and G01. |
| Fluoride (sodium) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Italy | OTC | — |
| Carbenoxolone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | N.R. | Not registered or not marketed. |
| Aluminium hydroxide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | N.R. | Not registered or not marketed. |
| Pantoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2009 | Italy | OTC | Pantoprazole 20mg was switched to non-prescription status in the entire European Union through a Decision of the European Commission under the centralised procedure dated 12 June 2009. |
| Famotidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | Rx | Only a prescribed reimbursable product still on the market - dosage 40 mg. |
| Sucralfate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | OTC | Rx under ATC code A02. OTC under ATC code M01, in combination with ketoprofen. |
| Nizatidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | Rx | — |
| Lansoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | Rx | — |
| Cetraxate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | N.R. | Not registered or not marketed. |
| Omeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2011 | Italy | OTC | Omeprazole 20mg for the treatment of reflux symptoms (e.g. heartburn, acid regurgitation) in adults, once daily for 14 days. Pack sizes 7 or 14 tablets. |
| Calcium carbonate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | OTC | OTC only in combination. |
| Rabeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | Rx | — |
| Ranitidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2010 | Italy | OTC | 75mg tablets. |
| Cimetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1993 | Italy | OTC | Authorised with a maximum dose of 200mg. |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2013 | Italy | OTC | Esomeprazole 20mg was switched to non-prescription status under the centralised procedure in the entire European Union through a European Commission Decision dated 26 August 2013. It is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. Recommended daily dose: one 20mg gastroresistant tablet. Maximum duration of treatment: 2 weeks. |
| Propantheline | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | Rx | In combination with bromazepan. |
| Metoclopramide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | OTC | Dosage 5mg. |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | N.R. | Not registered or not marketed. |
| Mebeverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | Rx | — |
| Hyoscine butylbromide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | 1998 | Italy | OTC | — |
| Domperidone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | Rx | Back-switched. |
| Dimeticone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | OTC | In combination. OTC under ATC codes A02 and A07 (in combination with activated carbon). |
| Dicyclomine (Dicycloverine) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Italy | N.R. | Not registered or not marketed. |
| Hyoscine (Scopolamine) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A04. Antiemetics and antinauseants | — | Italy | OTC | Not registered or not marketed for ATC04. OTC for ATC A03 - anticholinergic. |
| Dimenhydrinate (diphenhydramine and 8-chlorotheophylline) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A04. Antiemetics and antinauseants | — | Italy | OTC | — |
| Hymecromone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A05. Bile and liver therapy | — | Italy | OTC | Without prescription (public advertising not allowed). |
| Macrogol (Polyethylene glycol 3350) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | 2010 | Italy | OTC | SOP (advertising not allowed). Dosage 5.9g powder only for adults. |
| Lactulose | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Italy | OTC | — |
| Lactitol | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Italy | OTC | — |
| Bisacodyl | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Italy | OTC | — |
| Picosulfate (sodium) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Italy | OTC | — |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Italy | Rx | — |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Italy | Rx | — |
| Nifuroxazide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Italy | N.R. | Not registered or not marketed. |
| Loperamide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | 1998 | Italy | OTC | — |
| Orlistat | A Alimentary tract and metabolism. Alimentary tract and metabolism | A08. Antiobesity preparations | 2009 | Italy | OTC | Orlistat 60 mg was switched to non-prescription status under the centralised procedure in the entire European Union through a European Commission Decision dated 12 January 2009. The switch was also implemented in Croatia, Norway and Switzerland. Orlistat 60mg has SOP (non-advertisable) status in Italy. |
| Vitamin A (Retinol) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A11. Vitamins | — | Italy | N.R. | Not registered or not marketed. |
| Selenium | A Alimentary tract and metabolism. Alimentary tract and metabolism | A12. Mineral supplements | — | Italy | N.R. | Not registered or not marketed. |
| Tranexamic acid | B Blood and blood forming organs. Blood and blood forming organs | B02. Antihemorrhagics | — | Italy | Rx | — |
| Ubidecarenone | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | Italy | OTC | Dosage 50mg. SOP (advertising not allowed). |
| Nitro-glycerine | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | Italy | Rx | — |
| Adenosine | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | Italy | Rx | Hospital use only. |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | Italy | OTC | SOP (behind the counter). |
| Lovastatin | C Cardiovascular system. Cardiovascular system | C10. Lipid modifying agents | — | Italy | Rx | — |
| Simvastatin | C Cardiovascular system. Cardiovascular system | C10. Lipid modifying agents | — | Italy | Rx | — |
| Econazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2007 | Italy | OTC | Without prescription - SOP (advertising not allowed). |
| Croconazole | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | Italy | N.R. | Not registered or not marketed. |
| Clotrimazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2007 | Italy | OTC | Dosage 1%. |
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