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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Hexetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Japan | N.R. | — |
| Fluoride (sodium) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | 2015 | Japan | OTC | Mouthwash preparation. Daily dose 5-10mg in children over 4 years. |
| Chlorhexidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A01. Stomatological preparations | — | Japan | OTC | Antimicrobial for external use. |
| Famotidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1997 | Japan | OTC | Tablets, powder, liquid formulation. 10mg per dose up to twice a day for adults and adolescents 15 years of age and over. |
| Sucralfate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1981 | Japan | OTC | Switched as a GI combination drug. Tablets, granules, powder, liquid formulation. 500mg a dose up to three times a day for adults and adolescents 15 years of age and older. |
| Omeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | Rx | — |
| Rabeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | Rx | — |
| Cimetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1997 | Japan | OTC | Tablets, micro granules. 100mg per dose up to three times a day for adults and adolescents 15 years of age and over. |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | Rx | — |
| Carbenoxolone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | N.R. | — |
| Pantoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | N.R. | — |
| Lansoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | Rx | — |
| Cetraxate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1987 | Japan | OTC | Switched as a GI combination drug. Tablet, granule formulations. 200mg a dose, three times a day for adults and adolescents 15 years of age and over. |
| Nizatidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2005 | Japan | OTC | Tablets, capsules, liquid formulation. 75mg a dose up to twice a day for adults and adolescents 15 years of age and over. |
| Calcium carbonate | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | OTC | — |
| Aluminium hydroxide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Japan | OTC | — |
| Ranitidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1997 | Japan | OTC | Tablets. 63mg per dose up to twice a day for adults and adolescents 15 years of age and over. Discontinued. |
| Hyoscine butylbromide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | 1987 | Japan | OTC | Tablets, capsules. 10mg per dose up to three times a day as Butylscopolamine bromide for adults and adolescents 15 years of age and over. |
| Domperidone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | Rx | — |
| Dimeticone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | OTC | — |
| Dicyclomine (Dicycloverine) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | OTC | — |
| Alverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | N.R. | — |
| Metoclopramide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | Rx | — |
| Mebeverine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | N.R. | — |
| Propantheline | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | — | Japan | Rx | — |
| Dimenhydrinate (diphenhydramine and 8-chlorotheophylline) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A04. Antiemetics and antinauseants | — | Japan | OTC | — |
| Hyoscine (Scopolamine) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A04. Antiemetics and antinauseants | — | Japan | OTC | — |
| Hymecromone | A Alimentary tract and metabolism. Alimentary tract and metabolism | A05. Bile and liver therapy | — | Japan | Rx | — |
| Bisacodyl | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Japan | OTC | — |
| Lactulose | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Japan | Rx | — |
| Macrogol (Polyethylene glycol 3350) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Japan | N.R. | Not registered as a medicine. |
| Lactitol | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Japan | Rx | — |
| Picosulfate (sodium) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | 1983 | Japan | OTC | Tablet formulation. Maximum dose 7.5mg per day as sodium picosulfate hydrate for adults and adolescents 15 years of age and over. For children between 11 and 14, maximum dose 4.5mg per day. |
| Diosmectite | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Japan | OTC | Micro granules. 3000mg per dose up to three times a day for adults and adolescents 15 years of age and over. For children aged between 11 and 14, 2/3 of the dose for adults. |
| Racecadotril | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Japan | N.R. | — |
| Loperamide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | 1989 | Japan | OTC | Capsule, tablet, film formulations. 0.5mg a dose, up to twice a day for adults and adolescents 15 years of age and over. |
| Nifuroxazide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | — | Japan | N.R. | — |
| Orlistat | A Alimentary tract and metabolism. Alimentary tract and metabolism | A08. Antiobesity preparations | — | Japan | N.R. | — |
| Vitamin A (Retinol) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A11. Vitamins | — | Japan | OTC | — |
| Selenium | A Alimentary tract and metabolism. Alimentary tract and metabolism | A12. Mineral supplements | — | Japan | N.R. | Marketed as food supplement only. |
| Tranexamic acid | B Blood and blood forming organs. Blood and blood forming organs | B02. Antihemorrhagics | — | Japan | OTC | Tablet, liquid formulations. For cough and cold, maximum 750mg or 280mg per day, respectively three times or up to four times a day. Additional indications for chloasma in 2007. (ATC code D11) |
| Ubidecarenone | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | 1990 | Japan | OTC | Tablets. 30mg per dose up to three times a day for adults and adolescents 15 years of age and over. |
| Nitro-glycerine | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | Japan | Rx | — |
| Adenosine | C Cardiovascular system. Cardiovascular system | C01. Cardiac therapy | — | Japan | OTC | Adenosine triphosphate disodium hydrate. Tablet formulation. As a combination drug with B-complex vitamins, 20mg a dose, three times a day for adults and adolescents 15 years of age and over. |
| Diosmin | C Cardiovascular system. Cardiovascular system | C05. Vasoprotectives | — | Japan | N.R. | — |
| Lovastatin | C Cardiovascular system. Cardiovascular system | C10. Lipid modifying agents | — | Japan | N.R. | — |
| Simvastatin | C Cardiovascular system. Cardiovascular system | C10. Lipid modifying agents | — | Japan | Rx | — |
| Croconazole | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | — | Japan | Rx | — |
| Clotrimazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 1980 | Japan | OTC | Liquid, ointment, cream, gel or powder-form spray formulations. 1% in a preparation. Apply 2-3 times a day. |
| Ciclopirox Olamine | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 1987 | Japan | OTC | Topical liquid formulation, cream. 1%, apply 2-3 times a day. |
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