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| Ingredient | ATC Level 1 | ATC Level 2 | Year Of Switch | Country | Status | Additional Information |
|---|---|---|---|---|---|---|
| Hydrocortisone (topical) | D Dermatologicals. Dermatologicals | D07. Corticosteroids, dermatological preparations | 1983 | Italy | OTC | Also OTC under ATC code C05 (in combination). |
| Diclofenac | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | 1983 | Italy | OTC | Oral use: 25mg/tablet OTC. Also OTC under ATC code A01. |
| Ibuprofen (oral) | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | 1984 | Italy | OTC | 200mg and 400mg dosages are OTC (advertising allowed) for adults and children over 12 years of age. SOP (advertising not allowed) when for children under 12 years of age and infants: dosage 100mg/5ml or suppositories 125mg or 60mg (infants). |
| Paracetamol | N Nervous system. Nervous system | N02. Analgesics | 1990 | Italy | OTC | OTC (advertising allowed) status for 500mg maximum. In combination, paracetamol is used in may non-prescription medicines and for different therapeutical uses. |
| Cimetidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 1993 | Italy | OTC | Authorised with a maximum dose of 200mg. |
| Nicotine (patch) | N Nervous system. Nervous system | N07. Other nervous system drugs | 1993 | Italy | OTC | — |
| Diclofenac (topical) | M Musculo-skeletal system. Musculo-skeletal system | M02. Topical products for joint and muscular pain | 1994 | Italy | OTC | — |
| Ibuprofen (topical) | M Musculo-skeletal system. Musculo-skeletal system | M02. Topical products for joint and muscular pain | 1994 | Italy | OTC | — |
| Naproxen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | 1994 | Italy | OTC | Also OTC (advertising allowed) under ATC code M02. |
| Hyoscine butylbromide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A03. Drugs for functional gastrointestinal disorders | 1998 | Italy | OTC | — |
| Loperamide | A Alimentary tract and metabolism. Alimentary tract and metabolism | A07. Antidiarrheals, intestinal antiinflammatory/antiinfective agents | 1998 | Italy | OTC | — |
| Levocabastine | R Respiratory system. Respiratory system | R01. Nasal preparations | 2001 | Italy | OTC | Also OTC (advertising allowed) since 2011 under ATC code S01. |
| Loratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2004 | Italy | OTC | Without prescription - SOP (advertising not allowed). |
| Econazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2007 | Italy | OTC | Without prescription - SOP (advertising not allowed). |
| Azelaic acid | D Dermatologicals. Dermatologicals | D10. Anti-acne preparations | 2007 | Italy | OTC | — |
| Clotrimazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2007 | Italy | OTC | Dosage 1%. |
| Aciclovir (topical) | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | 2007 | Italy | OTC | Aciclovir 5% - 2g and 3g. |
| Ketoconazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2007 | Italy | OTC | — |
| Clotrimazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | 2007 | Italy | OTC | Vaginal cream (2%) and tablets (100mg). |
| Antazoline | S Sensory organs. Sensory organs | S01. Ophthalmologicals | 2008 | Italy | OTC | In combination with naftazoline. |
| Penciclovir (topical) | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | 2008 | Italy | OTC | External use. |
| Terbinafine | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2008 | Italy | OTC | — |
| Dexketoprofen | M Musculo-skeletal system. Musculo-skeletal system | M01. Antiinflammatory and antirheumatic products | 2009 | Italy | OTC | 25mg tablets for the symptomatic treatment (short time) of general mild to moderate pain as: muscular, skeleton, dysmenorrhea, teeth. |
| Pantoprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2009 | Italy | OTC | Pantoprazole 20mg was switched to non-prescription status in the entire European Union through a Decision of the European Commission under the centralised procedure dated 12 June 2009. |
| Orlistat | A Alimentary tract and metabolism. Alimentary tract and metabolism | A08. Antiobesity preparations | 2009 | Italy | OTC | Orlistat 60 mg was switched to non-prescription status under the centralised procedure in the entire European Union through a European Commission Decision dated 12 January 2009. The switch was also implemented in Croatia, Norway and Switzerland. Orlistat 60mg has SOP (non-advertisable) status in Italy. |
| Macrogol (Polyethylene glycol 3350) | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | 2010 | Italy | OTC | SOP (advertising not allowed). Dosage 5.9g powder only for adults. |
| Ipratropium bromide | R Respiratory system. Respiratory system | R01. Nasal preparations | 2010 | Italy | OTC | In combination with xylometazoline. |
| Azelastine | R Respiratory system. Respiratory system | R01. Nasal preparations | 2010 | Italy | OTC | OTC (advertising allowed) under this ATC code. Without prescription - SOP (advertising not allowed) under ATC code S01 (switched in 2012). |
| Ranitidine | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2010 | Italy | OTC | 75mg tablets. |
| Omeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2011 | Italy | OTC | Omeprazole 20mg for the treatment of reflux symptoms (e.g. heartburn, acid regurgitation) in adults, once daily for 14 days. Pack sizes 7 or 14 tablets. |
| Ciclopirox Olamine | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2012 | Italy | OTC | OTC (advertising allowed) as nail polish. Other topical formulations with a dosage of 1% are classified as SOP (advertising not allowed). Also SOP under ATC code G01 as vaginal cream, suppositories or lather. |
| Metronidazole | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | 2012 | Italy | OTC | Without prescription - SOP (advertising not allowed). Also SOP under ATC code G01. |
| Isoconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | 2012 | Italy | OTC | SOP (behind the counter). |
| Cromoglicic acid | R Respiratory system. Respiratory system | R01. Nasal preparations | 2012 | Italy | OTC | OTC under ATC code R01 (in combination). SOP (behind the counter) under ATC code R01 and S01. |
| Amorolfine (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2012 | Italy | OTC | — |
| Miconazole (vaginal) | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G01. Gynecological antiinfectives and antiseptics | 2012 | Italy | OTC | SOP (behind the counter). |
| Silver sulphadiazine 1% | D Dermatologicals. Dermatologicals | D06. Antibiotics and chemotherapeutics for dermatological use | 2012 | Italy | OTC | Without prescription - SOP (advertising not allowed). Also SOP under ATC code D03. |
| Naftifine (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2012 | Italy | OTC | Dosage 1%, 30g - 30ml. SOP (advertising not allowed). |
| Miconazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2012 | Italy | OTC | Also without prescription - SOP (advertising not allowed) under ATC code A01. |
| Isoconazole (topical) | D Dermatologicals. Dermatologicals | D01. Antifungals for dermatological use | 2012 | Italy | OTC | Without prescription - SOP (advertising not allowed). |
| Esomeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | 2013 | Italy | OTC | Esomeprazole 20mg was switched to non-prescription status under the centralised procedure in the entire European Union through a European Commission Decision dated 26 August 2013. It is indicated for the short-term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults. Recommended daily dose: one 20mg gastroresistant tablet. Maximum duration of treatment: 2 weeks. |
| Clobetasone butyrate (topical) | D Dermatologicals. Dermatologicals | D07. Corticosteroids, dermatological preparations | 2013 | Italy | OTC | — |
| Ulipristal acetate | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | 2015 | Italy | OTC | Ulipristal acetate 30mg was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 7 January 2015. It is indicated for emergency contraception within 120 hours (5 days) of unprotected sexual intercourse or contraceptive failure. In Italy, it has SOP (advertising not allowed) status, but a prescription is necessary for girls under 18 years of age. |
| Levonorgestrel | G Genito urinary system and sex hormones. Genito urinary system and sex hormones | G03. Sex hormones and modulators of the genital system | 2016 | Italy | OTC | Levonorgestrel 1 TABLET, 1,5 mg was switched to non-prescription status via the centralised procedure. SOP (behnid the counter) status, but a prescription is necessary for girls under 18 years of age. |
| Fexofenadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2016 | Italy | OTC | Switched as OTC (120 mg), in the market from January 2017. |
| lidocaine / prilocaine | R Respiratory system. Respiratory system | R01. Nasal preparations | 2020 | Italy | OTC | Lidocaine/prilocaine 150 mg/ml + 50 mg/ml cutaneous spray, solution was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 27 August 2020. It is indicated for the treatment of primary premature ejaculation in adult men. |
| Desloratadine | R Respiratory system. Respiratory system | R06. Antihistamines for systemic use | 2020 | Italy | OTC | Desloratadine 5 mg film-coated tablets was switched to non-prescription status via the centralised procedure in the entire European Union through a European Commission Decision dated 24 November 2020. It is indicated indicated in adults for the relief of symptoms associated with: - allergic rhinitis - chronic idiopathic urticaria as initially diagnosed by a physician |
| Lactulose | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Italy | OTC | — |
| Rabeprazole | A Alimentary tract and metabolism. Alimentary tract and metabolism | A02. Drugs for acid related disorders | — | Italy | Rx | — |
| Lactitol | A Alimentary tract and metabolism. Alimentary tract and metabolism | A06. Laxatives | — | Italy | OTC | — |
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